Skip to contents

Create a PKNCAdata object.

Source: R/class-PKNCAdata.R
PKNCAdata.Rd

PKNCAdata() combines PKNCAconc and PKNCAdose objects and adds in the intervals for PK calculations.

Usage

PKNCAdata(data.conc, data.dose, ...)

# S3 method for class 'PKNCAconc'
PKNCAdata(data.conc, data.dose, ...)

# S3 method for class 'PKNCAdose'
PKNCAdata(data.conc, data.dose, ...)

# Default S3 method
PKNCAdata(
  data.conc,
  data.dose,
  ...,
  formula.conc,
  formula.dose,
  impute = NA_character_,
  intervals,
  units,
  options = list()
)

Arguments

data.conc

Concentration data as a PKNCAconc object or a data frame

data.dose

Dosing data as a PKNCAdose object (see details)

...

arguments passed to PKNCAdata.default

formula.conc

Formula for making a PKNCAconc object with data.conc. This must be given if data.conc is a data.frame, and it must not be given if data.conc is a PKNCAconc object.

formula.dose

Formula for making a PKNCAdose object with data.dose. This must be given if data.dose is a data.frame, and it must not be given if data.dose is a PKNCAdose object.

impute

Methods for imputation. NA for to search for the column named "impute" in the intervals or no imputation if that column does not exist, a comma-or space-separated list of names, or the name of a column in the intervals data.frame. See vignette("v08-data-imputation", package="PKNCA") for more details.

intervals

A data frame with the AUC interval specifications as defined in check.interval.specification(). If missing, this will be automatically chosen by choose.auc.intervals(). (see details)

units

A data.frame of unit assignments and conversions as created by pknca_units_table()

options

List of changes to the default PKNCA options (see PKNCA.options())

Value

A PKNCAdata object with concentration, dose, interval, and calculation options stored (note that PKNCAdata objects can also have results after a NCA calculations are done to the data).

Details

If data.dose is not given or is NA, then the intervals must be given. At least one of data.dose and intervals must be given.

See also

choose.auc.intervals(), pk.nca(), pknca_units_table()

Other PKNCA objects: PKNCAconc(), PKNCAdose(), PKNCAresults()