Calculate the (observed oral) clearance

Usage

pk.calc.cl(dose, auc)

Arguments

dose: the dose administered
auc: The area under the concentration-time curve.

Value

the numeric value of the total (CL) or observed oral clearance (CL/F)

Details

cl is dose/auc.

If dose is the same length as the other inputs, then the output will be the same length as all of the inputs; the function assumes that you are calculating for multiple intervals simultaneously. If the inputs other than dose are scalars and dose is a vector, then the function assumes multiple doses were given in a single interval, and the sum of the doses will be used for the calculation.

References

Gabrielsson J, Weiner D. "Section 2.5.1 Derivation of clearance." Pharmacokinetic & Pharmacodynamic Data Analysis: Concepts and Applications, 4th Edition. Stockholm, Sweden: Swedish Pharmaceutical Press, 2000. 86-7.