Calculate AUXC (AUC or AUMC) over an interval for IV bolus dosing with C0 back-extrapolation

Usage

pk.calc.auxciv.int(
  conc,
  time,
  start,
  end,
  time.dose,
  route = "extravascular",
  duration.dose = 0,
  auxc,
  fun_auxcint_last,
  options = list()
)

pk.calc.auciv.int(
  conc,
  time,
  start,
  end,
  time.dose,
  route = "extravascular",
  duration.dose = 0,
  auc,
  options = list()
)

pk.calc.aumciv.int(
  conc,
  time,
  start,
  end,
  time.dose,
  route = "extravascular",
  duration.dose = 0,
  aumc,
  options = list()
)

Arguments

conc, time: All concentrations and their times for the group
start, end: The start and end of the interval
time.dose, route, duration.dose: The dose times, routes, and durations for the group (route and duration.dose default to an extravascular dose, as for pk.calc.aucint(), so a bolus must be given as "intravascular" with a duration of zero)
auxc: The AUXC over the interval from the AUCint or AUMCint family
fun_auxcint_last: The AUClast-type AUXCint function (pk.calc.aucint.last() or pk.calc.aumcint.last()) used for the segment that is replaced
options: List of changes to the default PKNCA options (see PKNCA.options())
auc: The AUC over the interval from the AUCint family
aumc: The AUMC over the interval from the AUMCint family

Value

The AUXC over the interval with C0 back-extrapolated

Details

The interval must start at an IV bolus dose. The AUXC over the interval from the AUCint or AUMCint family (auxc) estimates the concentration at the start of the interval from the profile before the dose (see pk.calc.auxcint()), which is the trough rather than the concentration just after the bolus. The segment from the start of the interval to the first concentration after the dose is replaced by the one starting from \(C_0\), which is back-extrapolated with the methods of pk.calc.c0() from the concentrations after the dose that are within the interval and before the next dose (with BLQ and missing concentrations handled as the AUCint handles them). A concentration measured at the dose time is taken to be measured before the dose, as for interp.extrap.conc.dose(), so it is not used as \(C_0\).

An interval that starts at an IV infusion has nothing to back-extrapolate, so the AUXCint is returned unchanged; an interval that does not start at an IV dose gives NA.

Functions

pk.calc.auciv.int(): Calculate AUC over an interval for IV bolus dosing with C0 back-extrapolation
pk.calc.aumciv.int(): Calculate AUMC over an interval for IV bolus dosing with C0 back-extrapolation