Calculate AUXC (AUC or AUMC) for IV dosing with C0 back-extrapolation

Calculates AUC or AUMC for intravenous dosing, with optional back-extrapolation to C0.

Usage

pk.calc.auxciv(
  conc,
  time,
  c0,
  auxc,
  fun_auxc_last,
  ...,
  options = list(),
  check = TRUE
)

pk.calc.auciv(conc, time, c0, auc, ..., options = list(), check = TRUE)

pk.calc.auciv_pbext(auc, auciv)

pk.calc.aumciv(conc, time, c0, aumc, ..., options = list(), check = TRUE)

Arguments

conc: Measured concentrations
time: Time of the measurement of the concentrations
c0: The concentration at time 0, typically calculated using pk.calc.c0()
auxc: The AUXC calculated using conc and time without c0 (it may be calculated using any method)
fun_auxc_last: Function to calculate the AUXC for the last interval (e.g., pk.calc.auc.last or pk.calc.aumc.last)
...: For functions other than pk.calc.auxc, these values are passed to pk.calc.auxc
options: List of changes to the default PKNCA options (see PKNCA.options())
check: Run assert_conc_time()?
auc: The AUC calculated without C0 back-extrapolation
auciv: The AUC calculated using c0
aumc: The AUMC calculated using conc and time without c0

Value

The AUXC calculated using c0

pk.calc.auciv_pctbackextrap: The AUC percent back-extrapolated

Details

The AUXC for intravenous (IV) dosing extrapolates the AUXC back from the first measurement to time 0 using c0 and the AUXC calculated by another method (e.g., auclast or aumclast).

The calculation method takes the following steps:

time = 0 must be present in the data with a measured concentration.
The AUXC between time = 0 and the next time point is calculated (auxc_first).
The AUXC between time = 0 with c0 and the next time point is calculated (auxc_second).
The final AUXC is the initial AUXC plus the difference between the two AUXCs (auxc_final <- auxc + auxc_second - auxc_first).

The calculation for back-extrapolation is 100*(1 - auc/auciv).

Functions

pk.calc.auciv(): Calculate AUC for intravenous dosing with C0 back-extrapolation
pk.calc.auciv_pbext(): Calculate the percent back-extrapolated AUC for IV administration
pk.calc.aumciv(): Calculate AUMC for intravenous dosing with C0 back-extrapolation