Calculate the mean residence time (MRT) for single-dose data or linear multiple-dose data.

Calculate the mean residence time (MRT) for single-dose data or linear multiple-dose data.

Usage

pk.calc.mrt(auc, aumc)

pk.calc.mrt.iv(auc, aumc, duration.dose)

pk.calc.mrt.md(auctau, aumctau, aucinf, tau)

Arguments

auc

the AUC from 0 to infinity or 0 to tau

aumc

the AUMC from 0 to infinity or 0 to tau

duration.dose

The duration of the dose (usually an infusion duration for an IV infusion)

auctau

the AUC from time 0 to the end of the dosing interval (tau).

aumctau

the AUMC from time 0 to the end of the dosing interval (tau).

aucinf

the AUC from time 0 to infinity (typically using single-dose data)

tau

The dosing interval

Value

the numeric value of the mean residence time

Details

mrt is aumc/auc - duration.dose/2 where duration.dose = 0 for oral administration.

mrt.md is aumctau/auctau + tau*(aucinf-auctau)/auctau and should only be used for multiple dosing with equal intervals between doses. Note that if aucinf == auctau (as would be the assumption with linear kinetics), the equation becomes the same as the single-dose MRT.

Functions

• pk.calc.mrt.iv(): MRT for an IV infusion

• pk.calc.mrt.md(): MRT for multiple-dose data with nonlinear kinetics